Edited Unassigned: Script Error on NON Debugmode [27697]

Hi
When i turn of Debugmode to FALSE then i have Script Errors from ajaxcontroltoolkit.
Why?
Wha is wrong?

When i ignor this errors, none tool is working from toolkit.
When i use UpdatePanel and Timer with SriptManger from MS Ajax -> no Error.
Using UpdatePanel and Timer with ToolkitScriptManager, then an error occured on NON Debug-Mode
I'm an asp.net beginer and not see how is the error or what is wrong.
Ca anyone help me?

asp.net 4.0, Vs2012, AjaxControlToolkit 4.0, new Version
Zeile: 2
Fehler: Sys.WebForms.PageRequestManagerServerErrorException: Script entries not loaded yet.

thanks.