Because the the GetHashCode() method returns a different value in the 64bit environment from the 32bit environment you will get an exception stating that the script does not exist for the hashcode supplied. This is because the script manager uses the hashcode of the script name in a hash table to match it on the incoming request.
Here is the exception raised:
Message: Assembly "AjaxControlToolkit, Version=1.0.10920.32880, Culture=neutral, PublicKeyToken=28f01b0e84b6d53e" does not contain a script with hash code "9ea3f0e2".
Stack trace: at AjaxControlToolkit.ToolkitScriptManager.DeserializeScriptEntries(String serializedScriptEntries, Boolean loaded)
at AjaxControlToolkit.ToolkitScriptManager.OnLoad(EventArgs e)
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Page.ProcessRequestMain(Boolean includeStagesBeforeAsyncPoint, Boolean includeStagesAfterAsyncPoint)
Comments: It seems that this error is caused by ToolkitScriptManager. Starting with the v15.1 release, we have removed it. So now, this problem is resolved.
Here is the exception raised:
Message: Assembly "AjaxControlToolkit, Version=1.0.10920.32880, Culture=neutral, PublicKeyToken=28f01b0e84b6d53e" does not contain a script with hash code "9ea3f0e2".
Stack trace: at AjaxControlToolkit.ToolkitScriptManager.DeserializeScriptEntries(String serializedScriptEntries, Boolean loaded)
at AjaxControlToolkit.ToolkitScriptManager.OnLoad(EventArgs e)
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Control.LoadRecursive()
at System.Web.UI.Page.ProcessRequestMain(Boolean includeStagesBeforeAsyncPoint, Boolean includeStagesAfterAsyncPoint)
Comments: It seems that this error is caused by ToolkitScriptManager. Starting with the v15.1 release, we have removed it. So now, this problem is resolved.